Brain mapping and synapse quantification in vivo: It’s time to imaging. Deciphering tacrolimus-induced toxicity in pancreatic β-cells. Triñanes J, Rodriguez-Rodriguez A, Brito-Casillas Y, Wagner A, De Vries APJ, Cuesto G, Acebes A, Salido E, Torres A, Porrini E.The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila. Jordán-Álvarez S, Santana E, Casas-Tintó S, Acebes A, Ferrús A.OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS: Lahoz F, Acebes A, González-Hernández T, de Armas-Rillo S, Soler-Carracedo K, Cuesto G, Mesa-Infante V.Inhibition of the mTOR pathway: A new mechanism of β cell toxicity induced by Tacrolimu Am J Transplant. Rodriguez-Rodriguez AE, Donate-Correa J, Rovira J, Cuesto G, Luis-Ravelo D, Fernandes MX, Acevedo-Arozena A, Diekmann F, Acebes A, Torres A, Porrini E.MICROFAVAR: Development of a high-resolution, high-speed quantitative phase-contrast microscope for 3D imaging of biological samples («Desarrollo de un microscopio de contraste de fase cuantitativa de alta resolución y alta velocidad para la obtención de imágenes en 3D de muestras biológicas»).Aid to promote dynamization actions «Research networks» («Ayudas para las acciones de dinamización “Redes de investigación”). Spanish Olfactory Network («Red olfativa española» – RED2018-102662-T).Laboratory intership abroad during the practical education of biological-technical Assistants (2019-1-DE02-KA102-005946).The Canary Islands Agency of Research, Innovation and Information Sciences (2017-2020, 70,000 €). (ProID2017010101 – “Enfermedad de Alzheimer: hacia un nuevo abordaje genético, molecular y celular”). A novel genetic, molecular and cellular approach to combat Alzheimer’s disease.Our main goal is to identify and validate pro-synaptic tools with the potential to be used as therapies in human neurodegenerative diseases. In both animal models, overexpression of the phosphoinositide-3-kinase (PI3K) synaptogenic tool will take place early in the development to increase the number of synapses, and to restore sensory and neuronal deficits generated after genetically and pharmacologically induced neurodegeneration. Using genetic and molecular tools in Drosophila melanogaster and transgenic mouse models, we analyse the effect of increasing the number of synapses in vivo in animal models during the early onset of Alzheimer’s disease (AD), characterized by the extensive loss of Synaptic Connections. Ninovska Romero Luis (Health Sciences Doctoral Programme, contracted by Project ProID2017010101, until July 2019).Carlos Cairós, PhD («Agustín de Betancourt» Researcher Department of Basic Medical Sciences, ULL, ULL, since January 2020).

Elena Quintana, PhD ACIISI (Postdoctoral Researcher, The Canary Islands Agency for Research, Innovation and Information Sciences, ACIISI, ProID2017010101, ULL).Contracted Lecturer, Doctor in Physiology, Department of Basic Medical Sciences, ULL

Microscopio contraste de fase